{"id":235,"date":"2024-10-10T05:30:37","date_gmt":"2024-10-10T05:30:37","guid":{"rendered":"https:\/\/ixchiq.ca\/hcp\/?page_id=235"},"modified":"2025-03-27T13:38:46","modified_gmt":"2025-03-27T13:38:46","slug":"efficacy-profile","status":"publish","type":"page","link":"https:\/\/ixchiq.ca\/hcp\/efficacy-profile\/","title":{"rendered":"Efficacy profile"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"235\" class=\"elementor elementor-235\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c347a03 e-flex e-con-boxed e-con e-parent\" data-id=\"c347a03\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-93649ef e-con-full e-flex e-con e-child\" data-id=\"93649ef\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51c7a99d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"51c7a99d\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2286bf3f elementor-widget elementor-widget-heading\" data-id=\"2286bf3f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">CLINICAL DATA: STUDY DESIGN<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-929d25c e-con-full e-flex e-con e-child\" data-id=\"929d25c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f49ff11 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"f49ff11\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">THE EFFICACY PROFILE OF IXCHIQ\u2122 WAS EVALUATED IN A DOUBLE-BLIND, RANDOMIZED PLACEBO-CONTROLLED PHASE 3 TRIAL<sup>1,25<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-740bbb2 e-con-full e-flex e-con e-child\" data-id=\"740bbb2\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8148c76 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"8148c76\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">PHASE 3: A PIVOTAL, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL<sup>1,25<\/sup>*<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9164f6 e-con-full elementor-hidden-mobile e-flex e-con e-child\" data-id=\"d9164f6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2989e97 elementor-absolute elementor-widget elementor-widget-text-editor\" data-id=\"2989e97\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tRandomization 3:1\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2586e elementor-widget elementor-widget-image\" data-id=\"7b2586e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1731\" height=\"336\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2.png\" class=\"attachment-full size-full wp-image-1719\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2.png 1731w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2-300x58.png 300w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2-1024x199.png 1024w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2-768x149.png 768w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/image-2-1536x298.png 1536w\" sizes=\"(max-width: 1731px) 100vw, 1731px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-04c1693 e-con-full elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet e-flex e-con e-child\" data-id=\"04c1693\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a9351c8 elementor-widget elementor-widget-image\" data-id=\"a9351c8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"345\" height=\"646\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-1.png\" class=\"attachment-full size-full wp-image-1727\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-1.png 345w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-1-160x300.png 160w\" sizes=\"(max-width: 345px) 100vw, 345px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e85346f elementor-widget elementor-widget-text-editor\" data-id=\"e85346f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tRecruitment was stratified by age (18\u201364 years and \u226565 years)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e2d82dd e-con-full e-flex e-con e-child\" data-id=\"e2d82dd\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-072eee3 e-con-full e-flex e-con e-child\" data-id=\"072eee3\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8ca5826 elementor-widget elementor-widget-heading\" data-id=\"8ca5826\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">PRIMARY IMMUNOGENICITY ENDPOINT<sup>1,25<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3793ff3 e-con-full e-flex e-con e-child\" data-id=\"3793ff3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-b1444cd e-con-full e-flex e-con e-child\" data-id=\"b1444cd\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d14bab0 elementor-widget elementor-widget-heading\" data-id=\"d14bab0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Seroresponse rate (SRR), the surrogate immunogenicity endpoint of efficacy<sup>\u2020<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a181d32 elementor-widget elementor-widget-text-editor\" data-id=\"a181d32\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Defined as achieving a virus neutralizing antibody \u03bcPRNT<sub>50<\/sub> titer \u2265150, which was considered to predict a clinical benefit, for baseline negative participants 28 days post-vaccination<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fef773c e-con-full e-flex e-con e-child\" data-id=\"fef773c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e8ecc3e elementor-widget elementor-widget-heading\" data-id=\"e8ecc3e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">SECONDARY IMMUNOGENICITY ENDPOINT<sup>1,25<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3436d2c e-con-full e-flex e-con e-child\" data-id=\"3436d2c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-3038d5d e-con-full e-flex e-con e-child\" data-id=\"3038d5d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6b75f7a elementor-widget elementor-widget-text-editor\" data-id=\"6b75f7a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The immune response as measured by chikungunya virus-specific neutralising antibody titres on Day 8, Day 29, Day 85, and at Month 6 post-vaccination as determined by \u03bcPRNT assay.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eecdb37 e-flex e-con-boxed e-con e-parent\" data-id=\"eecdb37\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8ae10c elementor-widget elementor-widget-heading\" data-id=\"a8ae10c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>* Double-blind, randomized placebo controlled trial of 4115 adults (1864 M; 2251 F) aged 18-94. Study subjects received either IXCHIQ\u2122 1\u00d710E4 TCID<sub>50<\/sub> per 0.5 mL or placebo (phosphate buffered saline) via intramuscular injection as a single dose with 6 month follow up. Healthy adult men and women were enrolled without prior known or suspected chikungunya virus infections and unlikely to become exposed to chikungunya virus during the study. Subjects with chronic illnesses or conditions that were stable and well-controlled on therapy for the past 6 months were eligible to participate in the clinical study. Immuno-compromised subjects were not eligible to participate in the clinical study.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0753b2f elementor-widget elementor-widget-heading\" data-id=\"0753b2f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>\u2020 This is based on nonclinical data from a non-human primate pharmacology study showing that animals treated with immune sera from clinical samples collected in Study VLA1553-101 were protected against mild CHIKV disease induced by challenge with a WT CHIKV strain. Pre-challenge neutralizing antibody titer level about 150 resulted in undetectable virus during 14 days after the challenge.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b8d0367 e-con-full e-flex e-con e-parent\" data-id=\"b8d0367\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adad769 elementor-widget elementor-widget-image\" data-id=\"adad769\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"198\" height=\"198\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon.jpg\" class=\"attachment-full size-full wp-image-933\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon.jpg 198w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon-150x150.jpg 150w\" sizes=\"(max-width: 198px) 100vw, 198px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2863301 e-flex e-con-boxed e-con e-parent\" data-id=\"2863301\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-637af19 e-con-full e-flex e-con e-child\" data-id=\"637af19\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74e9bc7 elementor-widget elementor-widget-heading\" data-id=\"74e9bc7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">PRIMARY IMMUNOGENICITY ENDPOINT<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f8de4d elementor-widget elementor-widget-heading\" data-id=\"4f8de4d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">Strong SRRs demonstrated in a pivotal study<sup>1,25*<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ae3e19 elementor-widget elementor-widget-heading\" data-id=\"6ae3e19\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">IXCHIQ\u2122 INDUCED A SERORESPONSE IN 98.9% OF PARTICIPANTS 28 DAYS AFTER A SINGLE DOSE<sup>1,25\u2020\u2021<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c59104 elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"9c59104\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2377\" height=\"1449\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5.png\" class=\"attachment-full size-full wp-image-1937\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5.png 2377w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5-300x183.png 300w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5-1024x624.png 1024w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5-768x468.png 768w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5-1536x936.png 1536w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Untitled-5-2048x1248.png 2048w\" sizes=\"(max-width: 2377px) 100vw, 2377px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f259e18 elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"f259e18\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1028\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/teb.png\" class=\"attachment-full size-full wp-image-1703\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/teb.png 1000w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/teb-292x300.png 292w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/teb-996x1024.png 996w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/teb-768x790.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e13c5f7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e13c5f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tAdapted from the IXCHIQ\u2122 Product Monograph and Schneider <em>et al.<\/em> <sup>1,25<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1c5e190 e-flex e-con-boxed e-con e-parent\" data-id=\"1c5e190\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9cb8c2f e-con-full e-flex e-con e-child\" data-id=\"9cb8c2f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6c7d35f elementor-widget elementor-widget-heading\" data-id=\"6c7d35f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">HIGH SRRs WERE OBSERVED AT 28 DAYS POST-VACCINATION AND SUSTAINED AT 180 DAYS POST-VACCINATION<sup>1,25\u2021<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b8ee2fd e-con-full e-flex e-con e-child\" data-id=\"b8ee2fd\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2a950e1 e-con-full e-flex e-con e-child\" data-id=\"2a950e1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ff08a4 elementor-widget elementor-widget-heading\" data-id=\"5ff08a4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">28 days post-vaccination<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1730660 elementor-widget elementor-widget-image\" data-id=\"1730660\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"296\" height=\"305\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_98Percent.png\" class=\"attachment-full size-full wp-image-927\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_98Percent.png 296w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_98Percent-291x300.png 291w\" sizes=\"(max-width: 296px) 100vw, 296px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-134bee8 elementor-widget elementor-widget-heading\" data-id=\"134bee8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">(<i>p<\/i>&lt;0\u00b70001; 95% CI: 96.7, 99.8)<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b69477 e-con-full e-flex e-con e-child\" data-id=\"7b69477\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8623699 elementor-widget elementor-widget-heading\" data-id=\"8623699\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">180 days post-vaccination<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20e6639 elementor-widget elementor-widget-image\" data-id=\"20e6639\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"296\" height=\"305\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_96Percent.png\" class=\"attachment-full size-full wp-image-926\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_96Percent.png 296w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_96Percent-291x300.png 291w\" sizes=\"(max-width: 296px) 100vw, 296px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e3ec6c3 elementor-widget elementor-widget-heading\" data-id=\"e3ec6c3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">(95% CI: 93.1, 98.3)<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8da9f98 e-flex e-con-boxed e-con e-parent\" data-id=\"8da9f98\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96cbffd elementor-widget elementor-widget-heading\" data-id=\"96cbffd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"icon_flex\"><span>*<\/span><span>Percentage of participants with neutralizing antibody titers above the threshold of \u2265150 determined by \u03bcPRNT<sub>50<\/sub> titer.<\/span><\/div>\n<div class=\"icon_flex\"><span>\u2020<\/span><span>Success criterion: lower bound of the 95% CI for SRR &gt;70%.<\/span><\/div>\n<div class=\"icon_flex\"><span>\u2021<\/span><span>Clinical significance unknown.<\/span><\/div>\n<div class=\"icon_flex\"><span>SRR:<\/span><span>seroresponse rate; CI: confidence interval; \u03bcPRNT: micro plaque reduction neutralization test.<\/span><\/div> <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-42e1b42 e-con-full e-flex e-con e-parent\" data-id=\"42e1b42\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e021790 elementor-widget elementor-widget-image\" data-id=\"e021790\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"198\" height=\"198\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon.jpg\" class=\"attachment-full size-full wp-image-933\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon.jpg 198w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/study-icon-150x150.jpg 150w\" sizes=\"(max-width: 198px) 100vw, 198px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-37f1b88 e-flex e-con-boxed e-con e-parent\" data-id=\"37f1b88\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d3f2f24 elementor-widget elementor-widget-heading\" data-id=\"d3f2f24\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">SECONDARY IMMUNOGENICITY ENDPOINT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f395d5c elementor-widget elementor-widget-heading\" data-id=\"f395d5c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">GMT of chikungunya virus-specific neutralizing antibodies on 28 days and 6 months post-vaccination (PP population)<sup>1*\u2020\u2021<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92e8b2a elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"92e8b2a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1785\" height=\"834\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29.jpg\" class=\"attachment-full size-full wp-image-949\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29.jpg 1785w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29-300x140.jpg 300w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29-1024x478.jpg 1024w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29-768x359.jpg 768w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/tbl-29-1536x718.jpg 1536w\" sizes=\"(max-width: 1785px) 100vw, 1785px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0fa8b66 e-con-full elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet e-flex e-con e-child\" data-id=\"0fa8b66\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1bbcc15 elementor-widget elementor-widget-image\" data-id=\"1bbcc15\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"658\" height=\"574\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/IXCHIQ_HCP_Website.jpg\" class=\"attachment-full size-full wp-image-1695\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/IXCHIQ_HCP_Website.jpg 658w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/IXCHIQ_HCP_Website-300x262.jpg 300w\" sizes=\"(max-width: 658px) 100vw, 658px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-488da37 elementor-widget elementor-widget-text-editor\" data-id=\"488da37\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tAdapted from the IXCHIQ\u2122 Product Monograph.<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26c9d71 e-flex e-con-boxed e-con e-parent\" data-id=\"26c9d71\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-214ae8b elementor-widget elementor-widget-heading\" data-id=\"214ae8b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>* Double-blind, randomized placebo controlled trial of 4115 adults (1864 M; 2251 F) aged 18\u201494. Study subjects received either IXCHIQ\u2122 1\u00d710E4 TCID<sub>50<\/sub> per 0.5 mL or placebo (phosphate buffered saline) via intramuscular injection as a single dose with 6 month follow up. Healthy adult men and women were enrolled without prior known or suspected chikungunya virus infections and unlikely to become exposed to chikungunya virus during the study. Subjects with chronic illnesses or conditions that were stable and well-controlled on therapy for the past 6 months were eligible to participate in the clinical study. Immuno-compromised subjects were not eligible to participate in the clinical study.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5b5744 elementor-widget elementor-widget-heading\" data-id=\"d5b5744\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">\u2020 As determined by \u03bcPRNT assay.<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72d018d elementor-widget elementor-widget-heading\" data-id=\"72d018d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">\u2021 Clinical significance unknown.<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab7d920 elementor-widget elementor-widget-heading\" data-id=\"ab7d920\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"icon_flex\"><span>GMT:<\/span><span>Geometric Mean Titer; PP: per-protocol; TCID<sub>50<\/sub>: 50% tissue culture infectious dose; CI: confidence interval; \u03bcPRNT: micro plaque reduction neutralization test.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-27a9425f e-flex e-con-boxed e-con e-parent\" data-id=\"27a9425f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3aa13736 elementor-align-right elementor-widget__width-inherit elementor-widget elementor-widget-button\" data-id=\"3aa13736\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ixchiq.ca\/hcp\/safety-profile\/\" id=\"btn_2\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">SAFETY PROFILE<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>CLINICAL DATA: STUDY DESIGN THE EFFICACY PROFILE OF IXCHIQ\u2122 WAS EVALUATED IN A DOUBLE-BLIND, RANDOMIZED PLACEBO-CONTROLLED PHASE 3 TRIAL1,25 PHASE 3: A PIVOTAL, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL1,25* Randomization 3:1 Recruitment was stratified by age (18\u201364 years and \u226565 years) PRIMARY IMMUNOGENICITY ENDPOINT1,25 Seroresponse rate (SRR), the surrogate immunogenicity endpoint of efficacy\u2020 Defined as achieving [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-235","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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