{"id":2199,"date":"2024-10-10T04:43:19","date_gmt":"2024-10-10T04:43:19","guid":{"rendered":"https:\/\/ixchiq.ca\/hcp\/safety-profile\/"},"modified":"2026-05-05T05:24:29","modified_gmt":"2026-05-05T05:24:29","slug":"profil-dinnocuite","status":"publish","type":"page","link":"https:\/\/ixchiq.ca\/hcp\/fr\/profil-dinnocuite\/","title":{"rendered":"Profil d\u2019innocuit\u00e9"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2199\" class=\"elementor elementor-2199 elementor-202\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4690d365 e-flex e-con-boxed e-con e-child\" data-id=\"4690d365\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b656290 e-con-full e-flex e-con e-child\" data-id=\"b656290\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1617d615 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1617d615\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-160cb119 elementor-widget elementor-widget-heading\" data-id=\"160cb119\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">IXCHIQ<sup>MD<\/sup> a d\u00e9montr\u00e9 un profil d\u2019innocuit\u00e9 g\u00e9n\u00e9ralement bien tol\u00e9r\u00e9<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20d61c3 e-con-full e-flex e-con e-child\" data-id=\"20d61c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11da149 elementor-widget elementor-widget-text-editor\" data-id=\"11da149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQ<sup>MD<\/sup> a \u00e9t\u00e9 \u00e9valu\u00e9 dans le cadre de l\u2019\u00e9tude VLA1553-301 chez des adultes de 18\u00a0ans ou plus s\u00e9ron\u00e9gatifs au d\u00e9part<sup>1<\/sup>*.<\/li>\n \t<li>Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQ<sup>MD<\/sup> a \u00e9t\u00e9 \u00e9valu\u00e9 chez des adolescents de 12 \u00e0 17\u00a0ans dans le cadre d\u2019un essai de phase\u00a0III \u00e0 r\u00e9partition al\u00e9atoire, \u00e0 double insu et contr\u00f4l\u00e9 par placebo<sup>1\u2020<\/sup>.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-936ad79 e-con-full e-flex e-con e-child\" data-id=\"936ad79\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d7cc92 elementor-widget elementor-widget-heading\" data-id=\"3d7cc92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Le tableau ci-dessous pr\u00e9sente les effets ind\u00e9sirables sollicit\u00e9s \u2013 syst\u00e9miques ou au point d\u2019injection \u2013 survenus dans les 10 jours suivant la vaccination chez les adultes et les adolescents (populations \u00e9valu\u00e9es sur l\u2019innocuit\u00e9). <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88d4598 elementor-widget elementor-widget-image\" data-id=\"88d4598\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2500\" height=\"843\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2.png\" class=\"attachment-full size-full wp-image-4290\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2.png 2500w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2-300x101.png 300w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2-1024x345.png 1024w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2-768x259.png 768w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2-1536x518.png 1536w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Untitled-1-2-2048x691.png 2048w\" sizes=\"(max-width: 2500px) 100vw, 2500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cdc4636 elementor-widget__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"cdc4636\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tD\u2019apr\u00e8s la monographie d\u2019IXCHIQ<sup>MD1<\/sup>.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f728832 elementor-widget elementor-widget-text-editor\" data-id=\"f728832\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>La majorit\u00e9 des r\u00e9actions ind\u00e9sirables syst\u00e9miques sollicit\u00e9es \u00e9taient <strong>d&rsquo;intensit\u00e9 l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e<\/strong> (&gt;\u00a095\u00a0% chez les adultes; &gt;\u00a094\u00a0% chez les adolescents s\u00e9ron\u00e9gatifs au d\u00e9part).<\/li>\n \t<li>Chez les adultes, les effets ind\u00e9sirables au point d&rsquo;injection et les effets ind\u00e9sirables syst\u00e9miques sont apparus apr\u00e8s une p\u00e9riode m\u00e9diane de 2\u00a0jours et de 5\u00a0jours, respectivement, apr\u00e8s la vaccination.<\/li>\n \t<li>Les effets ind\u00e9sirables locaux et syst\u00e9miques <strong>ont disparu apr\u00e8s une p\u00e9riode m\u00e9diane de 2\u00a0jours<\/strong> <strong>chez les adultes et de 1 \u00e0 2\u00a0jours chez les adolescents s\u00e9ron\u00e9gatifs au d\u00e9part<\/strong>.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-681b814 elementor-widget elementor-widget-heading\" data-id=\"681b814\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>* \u00c9tudes VLA1553-301, VLA1553-302 et VLA1553-101, toutes men\u00e9es en Am\u00e9rique du Nord chez des participants adultes en sant\u00e9 \u00e2g\u00e9s de 18&nbsp;ans ou plus. L\u2019\u00e9tude VLA1553-101, un essai compl\u00e9mentaire de phase&nbsp;I d\u2019augmentation de la dose d\u2019IXCHIQ<sup>MD<\/sup> chez 120&nbsp;participants, a \u00e9t\u00e9 r\u00e9alis\u00e9e avec une pr\u00e9paration ant\u00e9rieure. L\u2019\u00e9tude VLA1553-301 \u00e9tait l\u2019essai pivot de phase&nbsp;III men\u00e9 \u00e0 double insu et contr\u00f4l\u00e9 par placebo chez 4115&nbsp;participants ayant re\u00e7u une dose unique d\u2019IXCHIQ<sup>MD<\/sup> ou un placebo (solution saline tamponn\u00e9e au phosphate). L\u2019\u00e9tude VLA1553-302 \u00e9tait un essai compl\u00e9mentaire de phase&nbsp;III non contr\u00f4l\u00e9 par placebo portant sur l\u2019uniformit\u00e9 de trois lots d\u2019IXCHIQ<sup>MD<\/sup> administr\u00e9s en dose unique chez 408 participants. <\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f896c0 elementor-widget elementor-widget-heading\" data-id=\"3f896c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>\u2020&nbsp;L\u2019\u00e9tude VLA1553-321 a recrut\u00e9 754&nbsp;participants ayant re\u00e7u une dose unique (1&nbsp;\u00d7&nbsp;10<sup>4 <\/sup>TCID<sub>50<\/sub>) d\u2019IXCHIQ<sup>MD<\/sup> (n = 502) ou un placebo (n = 252) par injection intramusculaire, et ayant fait l\u2019objet d\u2019un suivi jusqu\u2019\u00e0 6 mois. En d\u00e9but d'\u00e9tude, 18,4 % des participants avaient des anticorps pr\u00e9existants contre le CHIKV, tandis que 81,4 % n'avaient jamais \u00e9t\u00e9 expos\u00e9s au CHIKV. La randomisation a \u00e9t\u00e9 stratifi\u00e9e selon le statut s\u00e9rologique en d\u00e9but d\u2019\u00e9tude vis-\u00e0-vis du CHIKV.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-04f7555 e-con-full e-flex e-con e-parent\" data-id=\"04f7555\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-195291f elementor-widget elementor-widget-image\" data-id=\"195291f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"301\" height=\"301\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people.jpg\" class=\"attachment-full size-full wp-image-1536\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people.jpg 301w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people-150x150.jpg 150w\" sizes=\"(max-width: 301px) 100vw, 301px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5c2d3e2 e-flex e-con-boxed e-con e-parent\" data-id=\"5c2d3e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7fcf786 elementor-widget elementor-widget-heading\" data-id=\"7fcf786\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Fr\u00e9quence des effets ind\u00e9sirables semblables \u00e0 ceux du chikungunya<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ab2b82 elementor-widget elementor-widget-text-editor\" data-id=\"3ab2b82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLes participants ont \u00e9t\u00e9 surveill\u00e9s pour un ensemble de sympt\u00f4mes correspondant aux sympt\u00f4mes typiques d&rsquo;une infection par le virus du chikungunya de type sauvage (effets ind\u00e9sirables semblables \u00e0 ceux du chikungunya), d\u00e9finis selon les crit\u00e8res suivants\u00a0:\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5871f25 e-con-full e-flex e-con e-child\" data-id=\"5871f25\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-220deaf e-con-full e-flex e-con e-child\" data-id=\"220deaf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c9318d6 elementor-widget elementor-widget-text-editor\" data-id=\"c9318d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>fi\u00e8vre (\u2265 38 \u00b0C dans l\u2019\u00e9tude VLA1553-301 ou \u2265 37,8 \u00b0C dans l\u2019\u00e9tude VLA1553-321) et un ou plusieurs des sympt\u00f4mes suivants\u00a0:<\/li>\n \t<li>arthralgie ou arthrite, myalgie, c\u00e9phal\u00e9es, dorsalgie (uniquement dans l\u2019\u00e9tude VLA1553-301), \u00e9ruptions cutan\u00e9es ou certains sympt\u00f4mes cutan\u00e9s, lymphad\u00e9nopathie (uniquement dans l&rsquo;\u00e9tude VLA1553-301), ou certains sympt\u00f4mes neurologiques, cardiaques (uniquement dans l&rsquo;\u00e9tude VLA1553-301) ou oculaires apparus dans les 30 jours suivant la vaccination, qu\u2019ils soient simultan\u00e9s ou non.<\/li>\n \t<li>Les sympt\u00f4mes graves semblables \u00e0 ceux du chikungunya sont ceux emp\u00eachant toute activit\u00e9 quotidienne et\/ou n\u00e9cessitant une intervention m\u00e9dicale.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4888ce3 e-flex e-con-boxed e-con e-parent\" data-id=\"4888ce3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-67b1abd e-con-full e-flex e-con e-child\" data-id=\"67b1abd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-feb26c5 elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"feb26c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">FREQUENCY OF SYMPTOMS AMONG PARTICIPANTS WITH CHIKUNGUNYA-LIKE ADVERSE REACTIONS (STUDY VLA1553-301)<sup>1<\/sup><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac5c5ba elementor-widget elementor-widget-html\" data-id=\"ac5c5ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"frm_tbl\"> \n<tr>\n<td>\u00c9tude VLA1553-301 <br\/> <b>Participants adultes (\u2265 18 ans)<\/b><\/td>\n<td>\u00c9tude VLA1553-321 <br\/> <b>Participants adolescents (12 \u00e0 17 ans; s\u00e9ron\u00e9gatifs au d\u00e9part)<\/b><\/td>\n<\/tr>\n<tr>\n<td>Dans le groupe IXCHIQ<sup>MD<\/sup>, 11,7 % des participants <span class=\"inline\">(n = 3082)<\/span> ont signal\u00e9 des effets ind\u00e9sirables de type chikungunya; 1,6 % pr\u00e9sentaient des sympt\u00f4mes graves. Dans le groupe placebo, 0,6 % des participants <span class=\"inline\">(n = 1033)<\/span> ont signal\u00e9 des effets ind\u00e9sirables de type chikungunya, aucun n\u2019\u00e9tant grave.<br\/><br\/>Dans le groupe IXCHIQ<sup>MD<\/sup>, les effets ind\u00e9sirables de type chikungunya sont apparus apr\u00e8s une p\u00e9riode m\u00e9diane de 3 jours (intervalle de 0 \u00e0 10 jours) apr\u00e8s la vaccination. La dur\u00e9e m\u00e9diane des effets ind\u00e9sirables de type chikungunya dans ce groupe \u00e9tait de 4 jours (intervalle de 1 jour \u00e0 au moins 6 mois). <\/td>\n<td>Dans le groupe IXCHIQ<sup>MD<\/sup>, 27 % des participants <span class=\"inline\">(n = 408)<\/span> ont signal\u00e9 des effets ind\u00e9sirables de type chikungunya; 4,2 % pr\u00e9sentaient des sympt\u00f4mes graves. Dans le groupe placebo, 3,9 % des participants s\u00e9ron\u00e9gatifs au d\u00e9part <span class=\"inline\">(n = 206)<\/span> ont signal\u00e9 des effets ind\u00e9sirables de type chikungunya, aucun n\u2019\u00e9tant grave.<\/td>\n<\/tr>\n<\/table> \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-486c65c elementor-widget elementor-widget-text-editor\" data-id=\"486c65c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tD\u2019apr\u00e8s la monographie d\u2019IXCHIQ<sup>MD1<\/sup>.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68b3f7b e-con-full e-flex e-con e-child\" data-id=\"68b3f7b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8826ab3 elementor-widget elementor-widget-text-editor\" data-id=\"8826ab3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div><strong><em>Adultes \u2013 effets ind\u00e9sirables de longue dur\u00e9e semblables \u00e0 ceux du chikungunya<\/em><\/strong><\/div>\n<div>Vingt-deux patients ayant re\u00e7u IXCHIQ<sup>MD<\/sup> ont pr\u00e9sent\u00e9 des effets ind\u00e9sirables prolong\u00e9s de type chikungunya, d\u2019une dur\u00e9e sup\u00e9rieure \u00e0 14 jours (dur\u00e9e m\u00e9diane de 33 jours, intervalle de 15 jours \u00e0 au moins 6 mois), et 15 patients ayant re\u00e7u IXCHIQ<sup>MD<\/sup> ont pr\u00e9sent\u00e9 des effets ind\u00e9sirables de type chikungunya d\u2019une dur\u00e9e sup\u00e9rieure \u00e0 28 jours (dur\u00e9e m\u00e9diane de 94 jours, intervalle de 29 jours \u00e0 au moins 6 mois). <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4099a04 elementor-widget elementor-widget-text-editor\" data-id=\"4099a04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div><strong><em>Adolescents s\u00e9ron\u00e9gatifs au d\u00e9part \u2013 effets ind\u00e9sirables de longue dur\u00e9e semblables \u00e0 ceux du chikungunya<\/em><\/strong><\/div>\n<div>Quinze patients ayant re\u00e7u IXCHIQ<sup>MD<\/sup> et 3 patients ayant re\u00e7u le placebo ont pr\u00e9sent\u00e9 des effets ind\u00e9sirables prolong\u00e9s de type chikungunya durant plus de 14 jours (dur\u00e9e m\u00e9diane de 23 jours, intervalle de 16 \u00e0 30 jours).<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8fd8968 e-flex e-con-boxed e-con e-parent\" data-id=\"8fd8968\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd4d079 elementor-widget elementor-widget-heading\" data-id=\"dd4d079\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">EFFETS IND\u00c9SIRABLES GRAVES<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f75c95 elementor-widget elementor-widget-heading\" data-id=\"8f75c95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Adultes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-caa9434 elementor-widget elementor-widget-text-editor\" data-id=\"caa9434\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>La proportion de participants ayant signal\u00e9 au moins un effet ind\u00e9sirable grave dans les 6\u00a0mois suivant l\u2019administration d\u2019IXCHIQ<sup>MD<\/sup> \u00e9tait de 1,5\u00a0% (46\/3082) dans le groupe IXCHIQ<sup>MD<\/sup> et de 0,8\u00a0% (8\/1033) dans le groupe placebo. Dans l\u2019ensemble, 2\u00a0effets ind\u00e9sirables graves (2\/3082 [0,1\u00a0%]) n\u00e9cessitant une hospitalisation ont \u00e9t\u00e9 consid\u00e9r\u00e9s comme \u00e9tant li\u00e9s \u00e0 IXCHIQ<sup>MD<\/sup> : 1\u00a0cas de myalgie et 1\u00a0cas d\u2019hyponatr\u00e9mie hypovol\u00e9mique et de fibrillation auriculaire; les deux cas se sont compl\u00e8tement r\u00e9tablis. Aucun \u00e9v\u00e9nement ind\u00e9sirable grave n\u2019a \u00e9t\u00e9 signal\u00e9 dans le groupe placebo.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff9d524 elementor-widget elementor-widget-heading\" data-id=\"ff9d524\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Adolescents s\u00e9ron\u00e9gatifs au virus du chikungunya au d\u00e9part <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9248448 elementor-widget elementor-widget-text-editor\" data-id=\"9248448\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>La proportion de participants s\u00e9ron\u00e9gatifs en d\u00e9but d&rsquo;\u00e9tude qui ont signal\u00e9 au moins un \u00e9v\u00e9nement ind\u00e9sirable grave dans les 6\u00a0mois suivant l&rsquo;administration \u00e9tait de 1,2\u00a0% (5\/408) dans le groupe ayant re\u00e7u IXCHIQ<sup>MD<\/sup> et de 1,0 % (2\/206) dans le groupe ayant re\u00e7u le placebo.<\/li>\n<\/ul> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46d8ebf elementor-widget elementor-widget-heading\" data-id=\"46d8ebf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">D\u00c9C\u00c8S ET \u00c9V\u00c9NEMENTS IND\u00c9SIRABLES AYANT ENTRA\u00ceN\u00c9 LE RETRAIT DE PARTICIPANTS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df6fa24 elementor-widget elementor-widget-text-editor\" data-id=\"df6fa24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>Trois participants sont d\u00e9c\u00e9d\u00e9s au cours de l&rsquo;\u00e9tude VLA1553\u2011301 en raison d&rsquo;\u00e9v\u00e9nements ind\u00e9pendants de l&rsquo;\u00e9tude (maladie coronarienne, COVID\u201119 et l\u00e9sion c\u00e9r\u00e9brale anoxique). <strong>Aucun de ces d\u00e9c\u00e8s n&rsquo;a \u00e9t\u00e9 consid\u00e9r\u00e9 comme \u00e9tant li\u00e9 \u00e0 IXCHIQ<sup>MD<\/sup>.<\/strong> Environ 0,1\u00a0% des participants ayant re\u00e7u IXCHIQ<sup>MD<\/sup> contre 0,2\u00a0% dans le groupe placebo ont interrompu leur participation \u00e0 l&rsquo;\u00e9tude en raison d&rsquo;\u00e9v\u00e9nements ind\u00e9sirables.<\/li>\n \t<li>Aucun participant n\u2019est d\u00e9c\u00e9d\u00e9 au cours de l\u2019\u00e9tude chez les adolescents (VLA1553-321) jusqu\u2019\u00e0 6 mois apr\u00e8s la vaccination.<\/li>\n<\/ul> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43da95e e-con-full e-flex e-con e-parent\" data-id=\"43da95e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f8c4852 elementor-widget elementor-widget-image\" data-id=\"f8c4852\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"301\" height=\"301\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people.jpg\" class=\"attachment-full size-full wp-image-1536\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people.jpg 301w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/10\/Ixchic_Icon_people-150x150.jpg 150w\" sizes=\"(max-width: 301px) 100vw, 301px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5fe0a11 e-flex e-con-boxed e-con e-parent\" data-id=\"5fe0a11\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-52cae3e elementor-widget elementor-widget-heading\" data-id=\"52cae3e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">DONN\u00c9ES DE PHARMACOVIGILANCE   <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8647351 elementor-widget elementor-widget-text-editor\" data-id=\"8647351\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"list\">\n \t<li>Apr\u00e8s la commercialisation, les effets ind\u00e9sirables graves apr\u00e8s vaccination par IXCHIQ<sup>MD<\/sup> ont \u00e9t\u00e9 le plus souvent signal\u00e9es chez les personnes m\u00e9dicalement fragiles pr\u00e9sentant des maladies chroniques avanc\u00e9es, chez les personnes \u00e2g\u00e9es (c.\u2011\u00e0\u2011d. \u2265\u00a065\u00a0ans, en particulier \u2265\u00a075\u00a0ans) et les personnes \u00e0 risque \u00e9lev\u00e9 d\u2019immunovuln\u00e9rabilit\u00e9 non diagnostiqu\u00e9e (p. ex., cancer occulte ou immunos\u00e9nescence).<\/li>\n \t<li><strong>Une r\u00e9actog\u00e9nicit\u00e9 s\u00e9v\u00e8re <\/strong>ou<strong> des effets ind\u00e9sirables semblables \u00e0 ceux du chikungunya <\/strong>chez les personnes m\u00e9dicalement fragiles pr\u00e9sentant des maladies chroniques peut entra\u00eener une d\u00e9t\u00e9rioration de l\u2019\u00e9tat g\u00e9n\u00e9ral, notamment malaise et perte d\u2019app\u00e9tit, aggravation de maladies pr\u00e9existantes, \u00e9tat confusionnel, enc\u00e9phalopathie ou enc\u00e9phalite, pouvant conduire \u00e0 des chutes, une hospitalisation et le d\u00e9c\u00e8s.<\/li>\n \t<li>Au cours de la p\u00e9riode de post-commercialisation, des cas suppl\u00e9mentaires d\u2019<strong>arthralgie prolong\u00e9e de type chikungunya <\/strong>d\u2019une dur\u00e9e allant de <strong>quelques semaines \u00e0 plus de 5\u00a0mois<\/strong> sont survenus apr\u00e8s la vaccination par IXCHIQ<sup>MD<\/sup>; dans quelques cas, un suivi en rhumatologie a \u00e9t\u00e9 n\u00e9cessaire.<\/li>\n \t<li><strong>Des cas d\u2019enc\u00e9phalite et d\u2019enc\u00e9phalopathie (y compris d\u2019issue fatale) <\/strong>ont \u00e9t\u00e9 signal\u00e9s chez des personnes \u00e2g\u00e9es de<strong> 74\u00a0ans ou plus pr\u00e9sentant de multiples comorbidit\u00e9s<\/strong>.<\/li>\n \t<li>Lors d\u2019une campagne de vaccination contre une \u00e9closion sur l\u2019\u00eele de La\u00a0R\u00e9union au d\u00e9but de 2025, <strong>trois d\u00e9c\u00e8s<\/strong> sont survenus dans les deux semaines suivant la vaccination chez des <strong>hommes \u00e2g\u00e9s \u00e0 la sant\u00e9 fragile pr\u00e9sentant de multiples comorbidit\u00e9s<\/strong> (troubles neurologiques avanc\u00e9s et affection respiratoire, pneumonie), attribuables \u00e0 une d\u00e9compensation m\u00e9dicale (88 et 77\u00a0ans) ou \u00e0 une enc\u00e9phalite confirm\u00e9e (84\u00a0ans). <strong>Un d\u00e9c\u00e8s<\/strong> serait probablement li\u00e9 \u00e0 la vaccination par IXCHIQ<sup>MD<\/sup> d\u2019apr\u00e8s les autorit\u00e9s sanitaires locales. <strong>Aucun d\u00e9c\u00e8s n\u2019a \u00e9t\u00e9 signal\u00e9<\/strong> chez les personnes ayant \u00e9t\u00e9 vaccin\u00e9es pour un voyage \u00e0 l\u2019\u00e9tranger.<\/li>\n<\/ul> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46b0536 elementor-widget elementor-widget-text-editor\" data-id=\"46b0536\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong><em>Les personnes vaccin\u00e9es doivent consulter rapidement un m\u00e9decin si elles pr\u00e9sentent tout sympt\u00f4me d\u00e9crit ci-dessus \u00e9voquant une r\u00e9actog\u00e9nicit\u00e9 s\u00e9v\u00e8re ou des effets ind\u00e9sirables graves de type chikungunya, une arthralgie prolong\u00e9e ou un trouble neurologique apr\u00e8s la vaccination.<\/em><\/strong> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ac2a25e e-flex e-con-boxed e-con e-parent\" data-id=\"ac2a25e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cf1c844 e-con-full e-flex e-con e-child\" data-id=\"cf1c844\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-52303c6 elementor-widget elementor-widget-heading\" data-id=\"52303c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">Effets ind\u00e9sirables observ\u00e9s apr\u00e8s la commercialisation dans les 30 jours suivant la vaccination par IXCHIQ<sup>MD<\/sup> <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9cf7ce4 elementor-widget elementor-widget-image\" data-id=\"9cf7ce4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2000\" height=\"2443\" src=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French.png\" class=\"attachment-full size-full wp-image-4333\" alt=\"\" srcset=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French.png 2000w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French-246x300.png 246w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French-838x1024.png 838w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French-768x938.png 768w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French-1257x1536.png 1257w, https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2026\/04\/Post-market-adverse-reactions-French-1677x2048.png 1677w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-47a32f5 e-flex e-con-boxed e-con e-parent\" data-id=\"47a32f5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fa971c4 elementor-widget elementor-widget-heading\" data-id=\"fa971c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Pour obtenir plus de renseignements sur les r\u00e9actions ind\u00e9sirables survenues pendant les \u00e9tudes cliniques, veuillez consulter la monographie d\u2019IXCHIQ<sup>MD<\/sup>.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-58fc805 elementor-widget elementor-widget-heading\" data-id=\"58fc805\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>* Donn\u00e9es sur l\u2019innocuit\u00e9 recueillies chez 4115&nbsp;participants \u00e0 l\u2019\u00e9tude clinique principale VLA1553\u2013301, randomis\u00e9s selon un rapport 3:1 pour recevoir IXCHIQ<sup>MD<\/sup> ou un placebo. Au total, 3082&nbsp;adultes en sant\u00e9 \u00e2g\u00e9s de 18 \u00e0 88&nbsp;ans ont re\u00e7u une dose unique d\u2019IXCHIQ<sup>MD<\/sup> (1&nbsp;\u00d7&nbsp;10<sup>4<\/sup>&nbsp;TCID<sub>50<\/sub>) et 1033 ont re\u00e7u un placebo par injection intramusculaire. Les participants ont fait l\u2019objet d\u2019un suivi pour l\u2019innocuit\u00e9 pendant 6 mois apr\u00e8s la vaccination. <\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe41473 elementor-widget elementor-widget-heading\" data-id=\"fe41473\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><div class=\"indent\"><span>\u2020 L\u2019\u00e9tude VLA1553-321 a recrut\u00e9 754&nbsp;participants ayant re\u00e7u une dose unique d'IXCHIQ<sup>MD<\/sup> (1&nbsp;\u00d7&nbsp;10<sup>4<\/sup>&nbsp;TCID<sub>50<\/sub>; n = 502) ou un placebo (n = 252) par injection intramusculaire, et ayant fait l\u2019objet d\u2019un suivi de 6 mois. Au d\u00e9but de l'\u00e9tude, 18,4 % des participants avaient des anticorps pr\u00e9existants contre le CHIKV, tandis que 81,4 % n'avaient jamais \u00e9t\u00e9 expos\u00e9s au CHIKV. La randomisation a \u00e9t\u00e9 stratifi\u00e9e selon le statut s\u00e9rologique en d\u00e9but d\u2019\u00e9tude vis-\u00e0-vis du CHIKV.<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-10e40ee e-flex e-con-boxed e-con e-parent\" data-id=\"10e40ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fdf311 elementor-align-right elementor-widget__width-inherit elementor-widget elementor-widget-button\" data-id=\"3fdf311\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/ixchiq.ca\/hcp\/fr\/posologie-et-reconstitution\/\" id=\"btn_2\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">POSOLOGIE ET RECONSTITUTION  <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>IXCHIQMD a d\u00e9montr\u00e9 un profil d\u2019innocuit\u00e9 g\u00e9n\u00e9ralement bien tol\u00e9r\u00e9 Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQMD a \u00e9t\u00e9 \u00e9valu\u00e9 dans le cadre de l\u2019\u00e9tude VLA1553-301 chez des adultes de 18\u00a0ans ou plus s\u00e9ron\u00e9gatifs au d\u00e9part1*. Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQMD a \u00e9t\u00e9 \u00e9valu\u00e9 chez des adolescents de 12 \u00e0 17\u00a0ans dans le cadre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2199","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Profil d\u2019innocuit\u00e9 - Ixchiq HCP<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixchiq.ca\/hcp\/fr\/profil-dinnocuite\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Profil d\u2019innocuit\u00e9 - Ixchiq HCP\" \/>\n<meta property=\"og:description\" content=\"IXCHIQMD a d\u00e9montr\u00e9 un profil d\u2019innocuit\u00e9 g\u00e9n\u00e9ralement bien tol\u00e9r\u00e9 Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQMD a \u00e9t\u00e9 \u00e9valu\u00e9 dans le cadre de l\u2019\u00e9tude VLA1553-301 chez des adultes de 18\u00a0ans ou plus s\u00e9ron\u00e9gatifs au d\u00e9part1*. Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQMD a \u00e9t\u00e9 \u00e9valu\u00e9 chez des adolescents de 12 \u00e0 17\u00a0ans dans le cadre [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ixchiq.ca\/hcp\/fr\/profil-dinnocuite\/\" \/>\n<meta property=\"og:site_name\" content=\"Ixchiq HCP\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-05T05:24:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ixchiq.ca\/hcp\/wp-content\/uploads\/2024\/11\/Untitleddd-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/\",\"url\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/\",\"name\":\"Profil d\u2019innocuit\u00e9 - Ixchiq HCP\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/Untitled-1-2.png\",\"datePublished\":\"2024-10-10T04:43:19+00:00\",\"dateModified\":\"2026-05-05T05:24:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/Untitled-1-2.png\",\"contentUrl\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/Untitled-1-2.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/profil-dinnocuite\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Profil d\u2019innocuit\u00e9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/\",\"name\":\"Ixchiq HCP\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#organization\",\"name\":\"Ixchiq HCP\",\"url\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/ixchiq-1.png\",\"contentUrl\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/ixchiq-1.png\",\"width\":500,\"height\":140,\"caption\":\"Ixchiq HCP\"},\"image\":{\"@id\":\"https:\\\/\\\/ixchiq.ca\\\/hcp\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Profil d\u2019innocuit\u00e9 - Ixchiq HCP","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ixchiq.ca\/hcp\/fr\/profil-dinnocuite\/","og_locale":"fr_FR","og_type":"article","og_title":"Profil d\u2019innocuit\u00e9 - Ixchiq HCP","og_description":"IXCHIQMD a d\u00e9montr\u00e9 un profil d\u2019innocuit\u00e9 g\u00e9n\u00e9ralement bien tol\u00e9r\u00e9 Le profil d\u2019innocuit\u00e9 et de tol\u00e9rabilit\u00e9 d\u2019IXCHIQMD a \u00e9t\u00e9 \u00e9valu\u00e9 dans le cadre de l\u2019\u00e9tude VLA1553-301 chez des adultes de 18\u00a0ans ou plus s\u00e9ron\u00e9gatifs au d\u00e9part1*. 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